Neutrophil CD64 has a high negative predictive value for exclusion of neonatal sepsis
نویسندگان
چکیده
منابع مشابه
Neutrophil CD64 as a diagnostic marker for neonatal sepsis: Meta-analysis.
BACKGROUND Neutrophil CD64 (nCD64) is a promising marker for diagnosing bacterial infections. Several studies have investigated the performance of nCD64 for diagnosing neonatal sepsis and the results are variable. Interest in nCD64 for detecting serious bacterial infections is increasing rapidly. OBJECTIVES The aim of the present study was to carry out a meta-analysis to systematically evalua...
متن کاملMeta-analysis of diagnostic accuracy of neutrophil CD64 for neonatal sepsis
BACKGROUND The aim of this study was to systematically evaluate the diagnostic performance of nCD64 for neonatal sepsis. METHODS Computer retrieval was conducted for the databases of PubMed, Embase, and Springer databases up to March 18, 2015 to select the relevant studies on nCD64 and neonatal sepsis. Sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR),...
متن کاملEvaluation of CD64 Expression on Peripheral Blood Neutrophils for Early Detection of Neonatal Sepsis
Background: Neonatal sepsis is a life-threatening disease with an incidence of 1 to 10 per 1000 live births and a mortality rate of 15% to 50%. The clinical signs are non-specific and indistinguishable from those caused by a variety of neonatal noninfectious disorders. Objective: The aim of this study was to determine the importance of CD64 expression (FcgRI), a neutrophil surface marker, in ea...
متن کاملNeutrophil CD64 as a diagnostic marker of sepsis in neonates.
BACKGROUND Sepsis in neonates hospitalized in the neonatal intensive care unit is a global problem and is a significant contributor to morbidity and mortality. Neutrophil surface CD64, the high-affinity Fc receptor, is quantitatively up-regulated during infection and sepsis. OBJECTIVE Our goal in this prospective study was to measure the neutrophil CD64 in blood as an adjunct to our previousl...
متن کاملRole of Neutrophil CD64 as an Emerging Biomarker in the Evaluation of Neonatal Sepsis
Results: We found high percentage of expression of CD64 on neutrophils in patients (67.73 ± 24.74) when compared with controls (8.19 ± 3.64) and also their percentage of expression was higher in culture positive sepsis (76.25 ± 29.07) than culture negative sepsis (42.21 ± 33.24). In the present study, I/T ratio >0.2 had a sensitivity, specificity, PPV, NPV and accuracy i.e. 70.0%, 72.0%, 33.3%,...
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ژورنال
عنوان ژورنال: South African Journal of Child Health
سال: 2013
ISSN: 1999-7671,1994-3032
DOI: 10.7196/sajch.482